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Objective
Following metabolic and bariatric surgery (MBS), most adolescents experience weight loss and improvement of many obesity‐associated complications (OACs). The relationship between weight loss and remission of OACs after MBS in adolescents has not been well described.
Methods
The Teen Longitudinal Assessment of Bariatric Surgery (Teen‐LABS) is a multi‐institutional prospective observational...
Objective
The inflammatory environment in lower‐body subcutaneous adipose tissue (SAT) has been largely unexplored. This study aimed to examine the effects of region (upper body vs. lower body) and sex on SAT immune cell profiles in young adults with obesity.
Methods
Abdominal (AB) and femoral (FEM) SAT was collected from 12 males (mean [SEM] age = 30.8 [1.4] years; mean [SEM] BMI = 34.1 [1.1]...
Objective
It remains unclear whether ethnicity has an impact on obesity independent of socioeconomic status (SES) and environmental factors. Singapore provides a unique opportunity to address this issue because three major Asian ethnic groups are represented, and government policies prevent ethnic segregation. Therefore this study examined associations between ethnicity, SES, and obesity within neighborhoods...
Objective
Ethnic differences in fat deposition contribute to type 2 diabetes (T2D). Identification of biomarkers that underpin dysglycemia are needed for better‐targeted prevention and treatment.
Methods
The cross‐sectional thin‐on‐the‐outside‐fat‐on‐the‐inside (TOFI)_Asia study investigated adipose depots and clinical biomarkers as predictors of fasting plasma glucose (FPG) and insulin resistance...
Objective
With the upsurge in interest in the gut microbiome, complete and accurate measurement of ingested calories and calories lost through excreted stool is crucial for assessing the effect of the microbiota on nutrient absorption.
Methods
Measurement of ingested and excreted calories was conducted over 3 days. Meals were made in duplicate: one was given to the participant, and one was used...
Objective
This study aimed to explore the relationship between an obesity diagnosis and weight loss as a percentage of total body weight loss over 9 to 15 months, using electronic health record data.
Methods
An observational study of 688,878 adult patients at 15 health systems with BMI ≥ 30 kg/m2 examined the relationship between weight loss and documentation of obesity diagnosis. Multivariable...
Objective
This study aimed to investigate both the long‐term and short‐term impacts of high‐fat diets (HFD) or high‐sucrose diets (HSD) on the normal diurnal pattern of cognitive function, protein expression, and the molecular clock in mice.
Methods
This study used both 6‐month and 4‐week feeding strategies by providing male C57BL/6J mice access to either a standard chow, HFD, or HSD. Spatial working...
Objective
This study aimed to evaluate (1) the effectiveness, complications, and postoperative access to transplantation in end‐stage chronic kidney disease (ECKD) and (2) the effectiveness and complications of bariatric surgery in patients who had already undergone kidney transplant.
Methods
A systematic review and meta‐analysis of mortality and complications rates were performed. Thirty studies...
Objective
Human conditions with upregulated receptor uptake of low‐density lipoproteins (LDL) are associated with diabetes risk, the reasons for which remain unexplored. LDL induce metabolic dysfunction in murine adipocytes. Thus, it was hypothesized that white adipose tissue (WAT) surface expression of LDL receptor (LDLR) and/or CD36 is associated with WAT and systemic metabolic dysfunction. Whether...
Objective
This study aimed to determine the impact of weight gain prevention interventions on changes in cardiovascular risk factors over 6 years.
Methods
The Study of Novel Approaches to Weight Gain Prevention (SNAP) randomized 599 participants (ages 18‐35; 46% with BMI 21‐25; 54% with BMI 25‐30) to Large Changes (produce buffer by losing 5‐10 pounds initially), Small Changes (daily small changes...
Objective
The purpose of this study was to investigate the association between maternal employment and infant BMI z score.
Methods
Longitudinal data from 520 mother‐infant dyads participating in the Nurture Study, an observational cohort in the southeastern United States, were leveraged. Women were categorized as employed or nonemployed at 3, 6, 9, and 12 months, and measured anthropometrics were...
Objective
This pilot study tested counselor access to participants’ digital self‐monitoring (SM) data as a means of improving long‐term lifestyle modification (LM) outcomes.
Methods
After 12 weeks of weight‐loss treatment, participants (N = 77) were randomized to LM or LM+SHARE for weeks 13 to 52. All participants received monthly phone calls and weekly text messages from weeks 13 to 52 and were...
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